Key West, Florida, is known for its lively nightlife, so it’s a great destination for solo trips, vacations with friends, or romantic getaways. If you’re looking for a place to reconnect with your partner or celebrate a special occasion, this is the place to be in the Florida Keys. There are plenty of fun things to do, like enjoying salt air and stunning views at Sunset Pier, spending the day at Smathers Beach, or grabbing a drink from a local pub. To enjoy everything this place has to offer, make sure you plan an all-inclusive vacation in Key West. For excellent accommodation, we’ve gathered some of the best adults-only hotels in this article. Enjoy high-end facilities and amenities on your vacation by booking one of these recommended accommodations. Read on to learn about the best adults-only hotels and other rentals in Key West, Florida.
We handpicked these listings carefully, considering (wherever possible) recent guest reviews, location, accommodation type, prices, availability of dates, decor, and access to adults-only amenities and services. The image galleries get refreshed with the latest updates regularly. They were last updated on October 27, 2025.
1. Ridley House (from USD 297)
Ridley House is the best place for a fun vacation in Key West. The hotel offers boutique-style rooms with bohemian designs for your stay. Book one of their adults-only accommodation and enjoy the complimentary breakfast served every morning between 8 am and 10 am.
Start your day by going for a swim at the outdoor pool before walking to the nearby Old Town Key West. Explore all the lively entertainments, restaurants, bars, and shops in the neighborhood, then return to your hotel room for a recharging nap. The hotel also has a spa package, where you can indulge in physical and mental well-being.
Ridley House - Key West Historic Inns
Address: 601 Caroline St
914 meters (0.6 ft) from The Hemingway Home and Museum
2. La Te Da - Adult Only
This pretty sophisticated party hotel is designed to be adult-only and is located in the very heart of Key West. The luxurious rooms are equipped with a flat-screen TV with cable channels, while complimentary toiletries are provided. Highlights of the hotel include an amazing pool surrounded by exotic trees, a fabulous cabaret theater on the second floor, an evening piano bar, and a world-class restaurant. Free wifi, wheelchair accessibility, and daily housekeeping are also provided for your convenience.
La Te Da - Adult Only, 21 or older
Address: 1125 Duval Street
330 meters (0.3 ft) from The Hemingway Home and Museum
3. The Gardens Hotel (from USD 786)
This adult-only, pet-friendly (on request) hotel is situated downtown Key West and enjoys great proximity to sandy Key West beaches and the Ernest Hemingway Home and Museum. Each guestroom comes with a fridge, a flat-screen TV, and ironing facilities, while a private balcony or patio is also featured.
It is also one of the luxury hotels with facilities that include massage therapy at extra charge, bicycle rental on-site, an adorable swimming pool with lounge chairs, yoga classes, and a library. This hotel can match a luxury lifestyle resort in Key West with its spa and wellness services. For the guests’ entertainment, there is live jazz music every Sunday in the premises’ gardens.
The Gardens Hotel This is a Proud Certified property where you can be extra sure of a welcoming stay.
Address: 526 Angela Street
352 meters (0.3 ft) from The Hemingway Home and Museum
Other adults-only properties
4. Marrero's Guest Mansion (from USD 280)
Marrero’s Guest Mansion is a beautiful boutique hotel that offers twelve guest rooms in a renovated home with all the modern comforts. This is the best place to stay in Key West for those looking for a peaceful vacation in the middle of bustling city life. It is conveniently located within walking distance of Duval Street, a popular street riddled with restaurants, bars, and shops.
Indulge in the modern comforts of this hotel and savor the continental breakfast, complete with coffee and bagels, served every morning between 8:30 am and 10 am. At 3:30 pm, step out of your room and enjoy the happy hour cocktails at the tiki bar. Savor your drinks while lounging by the saltwater pool under the parasols, or sit on the front porch to soak in the beautiful neighborhood views.
Marrero's Guest Mansion
Address: 410 Fleming Street
547 meters (0.4 ft) from The Hemingway Home and Museum
5. Simonton Court Historic Inn & Cottages (from USD 299)
Delicious and varied breakfast options, including oatmeal, waffles, French toast, and fruit.
Reasonably priced with great value for money.
Conveniently located just a block from Duval Street, close to bars, restaurants, and attractions.
Four pools, lush tropical gardens, cozy lights at night, and historic charm.
This stunningly tropical accommodation comprises of restored historic cottages spread around beautiful, landscaped gardens that enjoy proximity to major attractions of the area. All sizeable rooms feature a fridge, a TV, en-suite bathroom, a telephone, and also a balcony or patio. The property also boasts four lovely outdoor pools and they offer a light continental breakfast, and also bikes to rent. Idyllic Mallory Square, Duval Street and the Ernest Hemingway Home and Museum are all less than a three-minute drive away.
Simonton Court Historic Inn & Cottages
Address: 320 Simonton Street, Key West, Key West (FL), United States, FL 33040
801 meters (0.5 ft) from The Hemingway Home and Museum
6. Knowles House B&B - Adult Only (from USD 259)
Knowles House B&B is a beautifully restored 1800’s conch house, only five blocks away from Duval Street. Each room features a different theme and unique decoration, while it boasts a private bathroom with complimentary toiletries, a fridge, a cable TV, and free wifi as well. Among the facilities offered here is a great swimming pool complete with sun umbrellas, a gorgeous rooftop sundeck to enjoy your drink, free parking space, and happy hour. If you want to watch the sunset, head to the South Beach (1.5km/.9mi away).
Knowles House B&B - Adult Only
Address: 1004 Eaton Street
1.1 km (0.7 mi) from The Hemingway Home and Museum
7. The Cabana Inn Key West - Adult Exclusive (from USD 154)
Complimentary breakfast with waffles, fresh fruit, and cooked eggs, but limited variety; 24/7 Starbucks coffee, but some disappointment with happy hour snacks
Reasonable pricing for a Key West hotel, with complimentary breakfast and happy hour
Perfect location near Duval Street, walking distance to attractions, yet quiet and peaceful
Charming courtyard with pool, hot tub, and cabanas, 24-hour pool access, complimentary wine and snacks during happy hour
Another adult-only property, the Cabana Inn is located in the heart of Key West, nestled among beautiful trees and flowers. Each room is fitted with a flat-screen TV, and in some cases with a fridge and a microwave. Guests will be able to enjoy a dazzling swimming pool, hot tub, daily wine and cheese happy hour, a continental breakfast, and free wifi. A few white-sand beaches are an easy drive away, and similarly, several attractions like Nancy Forrester’s Secret Garden or the Fury Water Adventures are a very short walk away.
The Cabana Inn Key West - Adult Exclusive
Address: 413 Appelrouth Lane
463 meters (0.3 ft) from The Hemingway Home and Museum
8. Paradise Inn - Adult Exclusive (from USD 268)
Its name says it all: this adult-only inn is hidden amidst prolific vegetation featuring landscaped gardens and tropical turtles, making the place looking like a small paradise. Its welcoming and peaceful premises are ideal to help you relax and let go off your worries. All rooms come standard with a fridge, microwave, seating area with cable TV, wifi, and coffee facilities. Continental breakfast, complimentary wine, and cheese hour, along with a fabulous outdoor pool and a hot tub, are all featured here. Curry Mansion Museum is within easy walking distance.
Paradise Inn - Adult Exclusive
Address: 819 Simonton Street
289 meters (0.2 ft) from The Hemingway Home and Museum
9. H2O Suites- Adults Only (from USD 439)
Luxurious facilities are featured in these stunning, adult-only suites. Each suite is equipped with an iPod docking station, a flat-screen TV, en-suite bathroom fitted with bathrobes and slippers, and seating area with views over the tropical courtyard. Certain units feature also a private pool. You will never get bored here; sip your cocktail in the gorgeous sun terrace by the pool, hire bikes to explore the surroundings, stay at the bar for socializing, or indulge in a rejuvenating massage. The property stands 400 m (1,312 ft) far from the Southernmost Point.
H2O Suites- Adults Only
Address: 1212 Simonton Street
507 meters (0.4 ft) from The Hemingway Home and Museum
10. Southernmost Inn Adult Exclusive (from USD 128)
Tucked away in a quiet area of Key West, yet only minutes far from everything, this adult-only hotel is the perfect place to relax and unwind. All rooms are individually decorated in a unique tropical style, and they feature a flat-screen TV, A/C, and wifi. Among the facilities provided here, you will find two heated outdoor pools, a modern fitness center, a lovely outdoor patio, a poolside bar, and a hot tub, while continental breakfast is daily served. Southernmost Point is just around the corner, and likewise, white sand beaches are even closer.
Southernmost Inn Adult Exclusive
Address: 525 United Street
499 meters (0.4 ft) from The Hemingway Home and Museum
Relax in a tropical setting
Your holiday at any of the above-listed adults-only hotels in Key West guarantees a fabulous stay, so book any of these properties next time you visit Florida. There are also beachfront resorts and historic hotels available in the area for more accommodations. Enjoy your stay at the best resorts for adults in Key West and indulge in all the exciting things to do here.
Frequently asked questions about the best adults-only hotels and other rentals in Key West, Florida.
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