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Ayer is a historic American town in Middlesex County, Massachusetts and was originally a major railroad transportation hub. It borders the towns of Groton, Harvard, Littleton, and Shirley. Travelers have much to look forward to in the area such as visiting Ayer’s Main Street for dining and shopping, the Groton Town Forest for hiking, and Fort Devens Museum for its military exhibits. Check out our comprehensive list of Airbnb vacation rental in Ayer, Massachusetts and book your favorite one today!